ATG12 Protein (AA 101-141) (His tag)
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- Target See all ATG12 Proteins
- ATG12 (Autophagy Related 12 (ATG12))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 101-141
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Origin
- Human, Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ATG12 protein is labelled with His tag.
- Application
- ELISA, Western Blotting (WB), Mass Spectrometry (MS), Neutralization (Neut)
- Purity
- ~95 %
- Top Product
- Discover our top product ATG12 Protein
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Autophagy Related 12 (ATG12) (AA 1-140) protein (GST tag)
ATG12 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Autophagy Related 12 (ATG12) (AA 1-74) protein (GST tag)ATG12 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Autophagy Related 12 (ATG12) (AA 1-140) protein (His tag)Crystallography grade ATG12 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
Autophagy Related 12 (ATG12) (AA 1-141) protein (His tag)Crystallography grade ATG12 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
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- Application Notes
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 1X PBS containing 0.1 % SDS
- Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -80 °C
- Storage Comment
- Store in working aliquots at -70 °C.
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- Target
- ATG12 (Autophagy Related 12 (ATG12))
- Alternative Name
- ATG12 (ATG12 Products)
- Background
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). ATG12, another member of the autophagy protein family, forms a conjugate with ATG5 , this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy (4). This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells (5). ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7 (6).
- Molecular Weight
- 10 kDa (Calculated)
- Gene ID
- 9140
- OMIM
- 17366729
- UniProt
- O94817, Q9CQY1
- Pathways
- Autophagy
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