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XBP1 Protein (AA 2-160) (His tag)

XBP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant ~95 % WB, ELISA, MS, Neut
Catalog No. ABIN2469226
  • Target See all XBP1 Proteins
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 2-160
    Origin
    • 6
    • 3
    • 2
    • 1
    Human
    Source
    • 6
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This XBP1 protein is labelled with His tag.
    Application
    Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)
    Purity
    ~95 %
    Top Product
    Discover our top product XBP1 Protein
  • Application Notes
    This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    1X PBS containing 0.1 % SDS
    Handling Advice
    Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
    Storage
    -80 °C
    Storage Comment
    Store in working aliquots at -70 °C.
  • Target
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Alternative Name
    XBP1 (XBP1 Products)
    Synonyms
    treb5 Protein, xXBP1 Protein, xbp2 Protein, XBP1P1 Protein, XBPP1 Protein, xbp1 Protein, TREB5 Protein, XBP-1 Protein, XBP2 Protein, D11Ertd39e Protein, TREB-5 Protein, HTF Protein, cb918 Protein, id:ibd1195 Protein, trebf Protein, wu:fb02h05 Protein, wu:fb63f10 Protein, xbp1a Protein, xbp1b Protein, X-box binding protein 1 Protein, X-box binding protein 1 L homeolog Protein, xbp1 Protein, XBP1 Protein, Xbp1 Protein, xbp1.L Protein
    Background
    X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) (1). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).
    Molecular Weight
    25 kDa (Calculated)
    Gene ID
    7494
    OMIM
    18148382
    UniProt
    P17861
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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