XBP1 Protein (AA 2-160) (His tag)
-
- Target See all XBP1 Proteins
- XBP1 (X-Box Binding Protein 1 (XBP1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-160
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This XBP1 protein is labelled with His tag.
- Application
- Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)
- Purity
- ~95 %
- Top Product
- Discover our top product XBP1 Protein
-
-
- Application Notes
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- 1X PBS containing 0.1 % SDS
- Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -80 °C
- Storage Comment
- Store in working aliquots at -70 °C.
-
- Target
- XBP1 (X-Box Binding Protein 1 (XBP1))
- Alternative Name
- XBP1 (XBP1 Products)
- Synonyms
- treb5 Protein, xXBP1 Protein, xbp2 Protein, XBP1P1 Protein, XBPP1 Protein, xbp1 Protein, TREB5 Protein, XBP-1 Protein, XBP2 Protein, D11Ertd39e Protein, TREB-5 Protein, HTF Protein, cb918 Protein, id:ibd1195 Protein, trebf Protein, wu:fb02h05 Protein, wu:fb63f10 Protein, xbp1a Protein, xbp1b Protein, X-box binding protein 1 Protein, X-box binding protein 1 L homeolog Protein, xbp1 Protein, XBP1 Protein, Xbp1 Protein, xbp1.L Protein
- Background
- X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) (1). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).
- Molecular Weight
- 25 kDa (Calculated)
- Gene ID
- 7494
- OMIM
- 18148382
- UniProt
- P17861
- Pathways
- ER-Nucleus Signaling, Unfolded Protein Response
-