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CD74 Protein (His tag)

CD74 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. WB, ELISA Active
Catalog No. ABIN2566440
  • Target See all CD74 Proteins
    CD74 (HLA-DR-gamma (CD74))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 13
    • 11
    • 3
    Human
    Source
    • 10
    • 7
    • 4
    • 3
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This CD74 protein is labelled with His tag.
    Application
    Western Blotting (WB), ELISA
    Characteristics

    Measured by its binding ability in a functional ELISA. Immobilized human CD74 at 5 μg/mL (100 μL/well ) can bind biotinylated human CTSL1 with a linear range of 3. 2 - 500 ng/mL.

    Purity
    >95 % as determined by SDS-PAGE.
    Top Product
    Discover our top product CD74 Protein
  • Application Notes
    This recombinant protein can be used for WB, ELISA. For research use only.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Storage
    -80 °C,-20 °C
    Storage Comment
    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
  • Target
    CD74 (HLA-DR-gamma (CD74))
    Alternative Name
    CD74 (CD74 Products)
    Synonyms
    DHLAG Protein, HLADG Protein, II Protein, Ia-GAMMA Protein, CLIP Protein, Ii Protein, INVG34 Protein, Iclp-1 Protein, iclp1 Protein, wu:fb11f09 Protein, wu:fb12a01 Protein, wu:fb13d06 Protein, wu:fk94e07 Protein, Iclp-2 Protein, cd74 Protein, iclp2 Protein, zgc:123161 Protein, CD74 molecule Protein, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Protein, CD74 molecule, major histocompatibility complex, class II invariant chain a Protein, CD74 molecule, major histocompatibility complex, class II invariant chain b Protein, CD74 Protein, Cd74 Protein, cd74a Protein, cd74b Protein
    Background
    Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
    Molecular Weight
    19.3 kDa
    Gene ID
    972
    NCBI Accession
    NP_004346
    UniProt
    P04233
    Pathways
    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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