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Neuropilin 1 Protein (NRP1) (His tag)

NRP1 Origin: Human Host: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. WB, ELISA Active
Catalog No. ABIN2566805
  • Target See all Neuropilin 1 (NRP1) Proteins
    Neuropilin 1 (NRP1)
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 17
    • 8
    • 5
    • 1
    Human
    Source
    • 12
    • 11
    • 4
    • 3
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Neuropilin 1 protein is labelled with His tag.
    Application
    Western Blotting (WB), ELISA
    Characteristics

    Measured by its ability to bind with recombinant human VEGF165 in a functional ELISA.

    Purity
    >92 % as determined by SDS-PAGE.
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    Discover our top product NRP1 Protein
  • Application Notes
    This recombinant protein can be used for WB, ELISA. For research use only.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Storage
    -80 °C,-20 °C
    Storage Comment
    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
  • Target
    Neuropilin 1 (NRP1)
    Alternative Name
    Neuropilin 1 (NRP1 Products)
    Synonyms
    NRP1 Protein, cd304 Protein, neuropilin Protein, np-1 Protein, npn-1 Protein, nrp Protein, nrp-1 Protein, vegf165r Protein, BDCA4 Protein, CD304 Protein, NP1 Protein, NRP Protein, VEGF165R Protein, C530029I03 Protein, NP-1 Protein, NPN-1 Protein, Npn1 Protein, Nrp Protein, neuropilin 1 Protein, neuropilin 1 L homeolog Protein, NRP1 Protein, nrp1 Protein, Nrp1 Protein, nrp1.L Protein
    Background
    Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.
    Molecular Weight
    70.7 kDa
    Gene ID
    8829
    UniProt
    O14786
    Pathways
    Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals
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