Sclerostin Protein (SOST) (His tag)
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- Target See all Sclerostin (SOST) Proteins
- Sclerostin (SOST)
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Sclerostin protein is labelled with His tag.
- Application
- Western Blotting (WB)
- Purity
- >95 % as determined by SDS-PAGE.
- Top Product
- Discover our top product SOST Protein
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Sclerostin (SOST) (AA 24-213) protein (His-Avi Tag)
SOST Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) (AA 24-213) protein (His-Avi Tag,Biotin)SOST Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) (AA 69-258) protein (His tag)SOST Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) (AA 24-211) protein (His tag)SOST Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) protein (His tag)SOST Origin: Rat Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE
Sclerostin (SOST) (AA 24-213) protein (His tag)Crystallography grade SOST Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Sclerostin (SOST) (AA 24-211) protein (His tag)Crystallography grade SOST Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Sclerostin (SOST) (AA 24-213) protein (His tag,Biotin)SOST Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
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- Application Notes
- This recombinant protein can be used for WB. For research use only.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -80 °C,-20 °C
- Storage Comment
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- Target
- Sclerostin (SOST)
- Alternative Name
- Sclerostin (SOST Products)
- Synonyms
- LOC100313724 Protein, CDD Protein, VBCH Protein, 5430411E23Rik Protein, sclerostin Protein, LOC100313724 Protein, SOST Protein, Sost Protein
- Background
- Sclerostin (SOST) is also known as Sclerosteosis, VBCH, is a secreted glycoprotein with a signal peptide for secretion and a C-terminal cysteine knot-like (CTCK) domain and belongs to the Cerberus/DAN family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced by the osteocyte and has anti-anabolic effects on bone formation. More recently Sclerostin has been identified as binding to LRP5/6 receptors and inhibiting the Wnt signalling pathway. Wnt pathway inhibition under these circumstances is antagonistic to bone formation (meaning Sclerostin antagonizes bone formation). It has been shown that SOST binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. Sclerostin production by osteocytes is inhibited by parathyroid hormone, mechanical loading and cytokines including oncostatin M, cardiotrophin-1 and leukemia inhibitory factor. Sclerostin production is increased by calcitonin. Thus, osteoblast activity is self regulated by a negative feedback system. Mutations of Sclerostin is associated with the syndrome Sclerosteosis, and reduced sclerostin expression results in a milder form of the disorder called van Buchem disease.
- Molecular Weight
- 22.5 kDa
- Gene ID
- 50964
- UniProt
- Q9BQB4
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