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FGF7 Protein (AA 32-194)

FGF7 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis. BCA Active
Catalog No. ABIN2667546
  • Target See all FGF7 Proteins
    FGF7 (Fibroblast Growth Factor 7 (FGF7))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 32-194
    Origin
    • 20
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    Human
    Source
    • 19
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    Biochemical Assay (BCA)
    Purity
    >95 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
    Endotoxin Level

    Less than 0.1 ng per μg of protein.

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    Discover our top product FGF7 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Biological activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by KGF-responsive BaF3 cells is ≤ 10 ng/ml corresponding to a specific activity of ≥ 1 x 105 units/mg.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    For maximum results, quick spin vial prior to opening. Reconstitute in 20 mM Tris, pH 8.0 to a concentration of ≤1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer containing a carrier protein such as 0.1 % BSA and store working aliquots at -20 °C to -80 °C.
    Buffer
    Lyophilized, carrier-free.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    -20 °C
    Storage Comment
    Unopened vial can be stored at -20°C or -70°C.
  • Target
    FGF7 (Fibroblast Growth Factor 7 (FGF7))
    Alternative Name
    KGF (FGF7 Products)
    Synonyms
    HBGF-7 Protein, KGF Protein, Kgf Protein, kgf Protein, FGF-7 Protein, fgf7 Protein, fibroblast growth factor 7 Protein, fibroblast growth factor 7 L homeolog Protein, FGF7 Protein, Fgf7 Protein, fgf7 Protein, fgf7.L Protein
    Background
    KGF is a heparin binding growth factor secreted by cells of mesenchymal origin. KGF acts in a paracrine manner by binding exclusively to a splicing variant of FGF receptor 2, FGFR2-IIIB. FGFR-IIIB is predominatly expressed by epithelial cells. This suggests that KGF may play an important role in mesenchymal-epithelial communication. KGF can stimulate proliferation, migration, and differentiation of epithelial cells in a variety of tissues. In skin, KGF can be strongly upregulated in dermal fibroblasts after skin injury. KGF can induce keratinocyte proliferation and migration. KGF can also protect epithelial cells from reactive oxygen species. In liver, KGF is required for adult liver regeneration. In brain, KGF is important for inhibitory synapse formation in the hippocampus. KGF-deficient mice are prone to epileptic seizures induced by chemical kindling in adults. KGF signaling is also important for hair follicle development. Injection of recombinant KGF into adult athymic nude mice can induce dose-dependent hair growth. In lung, KGF can protect animals from oxidant-induced injury. Taken together, KGF is a potential target for epithelial tissue repair.
    Molecular Weight
    The 163 amino acid recombinant protein has a predicted molecular mass of approximately 18.9 kDa. The predicted N-terminal amino acid is Cys.
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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