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SETMAR Protein (DYKDDDDK Tag)

SETMAR Origin: Human Host: Baculovirus Recombinant EAA, ScA
Catalog No. ABIN2669702
  • Target See all SETMAR Proteins
    SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))
    Protein Type
    Recombinant
    Origin
    • 5
    • 1
    • 1
    • 1
    Human
    Source
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Baculovirus
    Purification tag / Conjugate
    This SETMAR protein is labelled with DYKDDDDK Tag.
    Application
    Enzyme Activity Assay (EAA), Screening Assay (ScA)
    Characteristics
    Recombinant SETMAR (accession number NP_006506.3) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 79 kDa.
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    Discover our top product SETMAR Protein
  • Application Notes
    Recombinant SETMAR is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
    Restrictions
    For Research Use only
  • Handling Advice
    Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
    Storage
    -80 °C
    Storage Comment
    Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
  • Target
    SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))
    Alternative Name
    SETMAR (SETMAR Products)
    Synonyms
    HsMar1 Protein, METNASE Protein, Mar1 Protein, 5830404F24Rik Protein, Etet2 Protein, SETMAR Protein, zgc:172212 Protein, SET domain and mariner transposase fusion gene Protein, SET domain without mariner transposase fusion Protein, histone-lysine N-methyltransferase SETMAR Protein, SETMAR Protein, Setmar Protein, LOC470738 Protein, setmar Protein, LOC703880 Protein, LOC100447656 Protein, LOC100586616 Protein
    Background
    SETMAR (SET Domain and mariner transposase fusion gene) is a ubiquitously expressed nuclear fusion protein that contains an N-terminal SET domain with histone methyltransferase activity and a C-terminal mariner (MAR) transposase domain that recognizes and binds DNA. The gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. SETMAR binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The mariner transposase domain recognizes and binds the 19-mer core of the 5'-TIR (terminal inverted repeats) of the Hsmar1 element. The SET domain specifically methylates lysines 4 and 36 of histone H3 which are epigenetic marks associated with transcriptional activation. SETMAR demonstrates in vivo end joining activity and may mediate genomic integration of foreign DNA.
    Molecular Weight
    79 kDa
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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