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SMARCA2 Protein (AA 1367-1511) (GST tag)

SMARCA2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Bind, ScA
Catalog No. ABIN2669725
  • Target See all SMARCA2 Proteins
    SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1367-1511
    Origin
    • 5
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This SMARCA2 protein is labelled with GST tag.
    Application
    Binding Studies (Bind), Screening Assay (ScA)
    Characteristics
    The peptide corresponding to amino acids 1367-1511 that contains the bromodomain sequences of SMARCA2 / BRM (accession number NP_003061.3) was expressed in E. coli and contains an N-terminal GST tag with an observed molecular weight of 44.2 kDa. It shows binding specificity for acetylated H3K9, H3K14, H3K9/14, H4K8, H4K12, H4K16 and H4K5/8/12/16.
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    Discover our top product SMARCA2 Protein
  • Application Notes
    Recombinant SMARCA2 / BRM (1367-1511), GST-tag is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
    Restrictions
    For Research Use only
  • Handling Advice
    Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
    Storage
    -80 °C
    Storage Comment
    Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
  • Target
    SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))
    Alternative Name
    SMARCA2 / BRM (SMARCA2 Products)
    Synonyms
    BAF190 Protein, BRM Protein, NCBRS Protein, SNF2 Protein, SNF2L2 Protein, SNF2LA Protein, SWI2 Protein, Sth1p Protein, hBRM Protein, hSNF2a Protein, brm Protein, 2610209L14Rik Protein, SNF2alpha Protein, Snf2l2 Protein, brahma Protein, psa-4 Protein, wu:fa56c07 Protein, wu:fi27f11 Protein, zgc:66238 Protein, Brahma Protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 L homeolog Protein, SMARCA2 Protein, smarca2.L Protein, Smarca2 Protein, smarca2 Protein
    Background
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), also known as BRM, is a member of the SWI/SNF family of proteins and is similar to the Brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. SMARCA2 contains bromodomains for interaction with other proteins. The bromodomain functions as a 'reader' of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. SMARCA2 is involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR). SMARCA1 belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). SMARCA2 plays a pivotal role in the regulation of the switch in subunit composition of the npBAF and nBAF complexes as cells transition from proliferating neural stem/progenitor cells to post-mitotic neurons during neural development.
    Molecular Weight
    44.2 kDa
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