Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Cullin 5 Protein (CUL5) (Myc-DYKDDDDK Tag)

CUL5 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2712634
  • Target See all Cullin 5 (CUL5) Proteins
    Cullin 5 (CUL5)
    Protein Type
    Recombinant
    Origin
    • 2
    • 1
    • 1
    Human
    Source
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Cullin 5 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Cullin-5 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product CUL5 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    Cullin 5 (CUL5)
    Alternative Name
    Cullin-5 (CUL5 Products)
    Synonyms
    cul5 Protein, wu:fd17d09 Protein, wu:fi20h12 Protein, xx:11fd17d09 Protein, zgc:66185 Protein, Xcullin5 Protein, CG1401 Protein, CUL5 Protein, Cul5 Protein, Cullin 5 Protein, Cullin5 Protein, Dmel\\CG1401 Protein, cul-5 Protein, vacm-1 Protein, vacm1 Protein, VACM-1 Protein, VACM1 Protein, 4921514I20Rik Protein, 8430423K24Rik Protein, AI852817 Protein, C030032G03Rik Protein, C330021I08Rik Protein, Cullin-5 Protein, cullin 5a Protein, cullin 5 L homeolog Protein, Cullin 5 Protein, cullin 5 Protein, Cullin-5 Protein, cul5a Protein, cul5.L Protein, Cul5 Protein, CUL5 Protein, cul5 Protein, cul-5 Protein
    Background
    Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. [UniProtKB/Swiss-Prot Function]
    Molecular Weight
    90.8 kDa
    NCBI Accession
    NP_003469
    Pathways
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
You are here:
Support