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CA8 Protein

CA8 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2713138
  • Target See all CA8 Proteins
    CA8 (Carbonic Anhydrase VIII (CA8))
    Protein Type
    Recombinant
    Origin
    • 7
    • 2
    • 1
    Human
    Source
    • 4
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Carbonic anhydrase 8 protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    Purity
    > 95 % as determined by SDS-PAGE and Coomassie blue staining
    Endotoxin Level
    < 0.1 EU per μg protein as determined by LAL test
    Top Product
    Discover our top product CA8 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    20 mM Tris-HCl, 500 mM NaCl, 1 mM DTT, pH 8.5. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    CA8 (Carbonic Anhydrase VIII (CA8))
    Alternative Name
    Carbonic Anhydrase 8 (CA8 Products)
    Synonyms
    AW546993 Protein, Ca8 Protein, Cals Protein, Cals1 Protein, Carp Protein, wdl Protein, zgc:110118 Protein, CA-VIII Protein, CALS Protein, CAMRQ3 Protein, CARP Protein, carbonic anhydrase 8 Protein, carbonic anhydrase VIII Protein, CAH8 Protein, Car8 Protein, ca8 Protein, CA8 Protein
    Background
    The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.
    Molecular Weight
    34 kDa
    NCBI Accession
    NP_004047
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