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CBFA2T2 Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)

CBFA2T2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2713251
  • Target See all CBFA2T2 Proteins
    CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 4
    Origin
    • 3
    • 1
    Human
    Source
    • 2
    • 2
    HEK-293 Cells
    Purification tag / Conjugate
    This CBFA2T2 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human CBFA2T2 (transcript variant 4) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product CBFA2T2 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
    Alternative Name
    Cbfa2t2 (CBFA2T2 Products)
    Synonyms
    MTGR1 Protein, A430091M07 Protein, C330013D05Rik Protein, Cbfa2t2h Protein, EHT Protein, ZMYND3 Protein, p85 Protein, XETOR Protein, cbfa2t2-a Protein, CBFA2/RUNX1 translocation partner 2 Protein, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) Protein, CBFA2/RUNX1 translocation partner 2 L homeolog Protein, Cbfa2t2 Protein, CBFA2T2 Protein, cbfa2t2.L Protein
    Background
    In acute myeloid leukemia, especially in the M2 subtype, the t(821)(q22q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5&apos-region of the RUNX1 (AML1) gene fused to the 3&apos-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
    Molecular Weight
    63.7 kDa
    NCBI Accession
    NP_001034798
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