CXCR2 Protein (Myc-DYKDDDDK Tag)
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- Target See all CXCR2 Proteins
- CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CXCR2 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human CD182 / IL8RB protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CXCR2 Protein
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Chemokine (C-X-C Motif) Receptor 2 (CXCR2) (AA 1-360) protein (GST tag)
CXCR2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Chemokine (C-X-C Motif) Receptor 2 (CXCR2) (AA 1-360) protein (Strep Tag)Crystallography grade CXCR2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Chemokine (C-X-C Motif) Receptor 2 (CXCR2) (AA 1-359) protein (Strep Tag)Crystallography grade CXCR2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
- Alternative Name
- Cd182,il8rb (CXCR2 Products)
- Synonyms
- CD182 Protein, CDw128b Protein, CMKAR2 Protein, IL8R2 Protein, IL8RA Protein, IL8RB Protein, CXC-R2 Protein, CXCR-2 Protein, CD128 Protein, CDw128 Protein, Cmkar2 Protein, Gpcr16 Protein, IL-8Rh Protein, IL-8rb Protein, Il8rb Protein, mIL-8RH Protein, C-X-C motif chemokine receptor 2 Protein, chemokine (C-X-C motif) receptor 2 Protein, Cxcr2 Protein, CXCR2 Protein
- Background
- The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
- Molecular Weight
- 40.6 kDa
- NCBI Accession
- NP_001548
- Pathways
- cAMP Metabolic Process
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