CDK2AP1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2713862

Product Details

Target: CDK2AP1 (Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CDK2AP1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human CDK2AP1 / DOC1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: CDK2AP1 (Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1))

Alternative Name: Cdk2ap1,doc1 (CDK2AP1 Products)

Synonyms: MGC64532 Protein, doc1 Protein, st19 Protein, doc-1 Protein, dorc1 Protein, p12doc-1 Protein, Apc10 Protein, Cdkap1 Protein, DORC1 Protein, Doc1 Protein, ST19 Protein, p12 Protein, DOC1 Protein, p12DOC-1 Protein, cyclin-dependent kinase 2 associated protein 1 S homeolog Protein, cyclin dependent kinase 2 associated protein 1 Protein, cyclin dependent kinase 2 associated protein 1 pseudogene Protein, cyclin-dependent kinase 2 associated protein 1 Protein, CDK2 (cyclin-dependent kinase 2)-associated protein 1 Protein, cdk2ap1.S Protein, CDK2AP1 Protein, LOC475806 Protein, cdk2ap1 Protein, Cdk2ap1 Protein

Background: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight: 12.2 kDa

NCBI Accession: NP_004633