NAE1 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2714845

Product Details

Target: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 3

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This NAE1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human APPBP1 (transcript variant 3) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Alternative Name: Appbp1 (NAE1 Products)

Synonyms: APPBP1 Protein, CG7828 Protein, Dmel\\CG7828 Protein, anon-WO0140519.225 Protein, dAPP-BP1 Protein, dAPPBP1 Protein, A-116A10.1 Protein, ula-1 Protein, Appbp1 Protein, 59kDa Protein, appbp1 Protein, zgc:66148 Protein, beta-Amyloid precursor protein binding protein 1 Protein, NEDD8 activating enzyme E1 subunit 1 Protein, NEDD8 activating enzyme E1 subunit 1 S homeolog Protein, nedd8 activating enzyme E1 subunit 1 Protein, NEDD8-activating enzyme E1 regulatory subunit Protein, APP-BP1 Protein, NAE1 Protein, Nae1 Protein, nae1.S Protein, nae1 Protein, ula-1 Protein

Background: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 50.4 kDa

NCBI Accession: NP_001018170