Axin Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Target See all Axin (AXIN1) Proteins
- Axin (AXIN1) (Axin 1 (AXIN1))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 2
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Axin protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Axin-1 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product AXIN1 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation." in: Nature chemical biology, Vol. 12, Issue 8, pp. 593-600, (2016) (PubMed).
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Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation." in: Nature chemical biology, Vol. 12, Issue 8, pp. 593-600, (2016) (PubMed).
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- Target
- Axin (AXIN1) (Axin 1 (AXIN1))
- Alternative Name
- Axin-1 (AXIN1 Products)
- Synonyms
- AXIN1 Protein, axin Protein, fused Protein, xAxin Protein, LOC100226467 Protein, AXIN Protein, PPP1R49 Protein, AI316800 Protein, Axin Protein, Fu Protein, Kb Protein, Ki Protein, kinky Protein, knobbly Protein, AXIN1-RGS Protein, wu:fi22e03 Protein, wu:fj14c08 Protein, wu:fk11b03 Protein, zgc:109872 Protein, axin 1 Protein, axin 1 S homeolog Protein, axin 1 L homeolog Protein, AXIN1 Protein, axin1.S Protein, axin1.L Protein, Axin1 Protein, axin1 Protein
- Background
- This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.
- Molecular Weight
- 91.5 kDa
- NCBI Accession
- NP_851393
- Pathways
- WNT Signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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