BCAR3 Protein (Myc-DYKDDDDK Tag)
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- Target See all BCAR3 Proteins
- BCAR3 (Breast Cancer Anti-Estrogen Resistance 3 (BCAR3))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This BCAR3 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human BCAR3 / SH2D3B protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product BCAR3 Protein
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Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) (AA 266-373) protein (GST tag)
BCAR3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) (AA 2-825) protein (His tag)Crystallography grade BCAR3 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) (AA 2-820) protein (His tag)Crystallography grade BCAR3 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- BCAR3 (Breast Cancer Anti-Estrogen Resistance 3 (BCAR3))
- Alternative Name
- Bcar3,sh2d3b (BCAR3 Products)
- Synonyms
- NSP2 Protein, SH2D3B Protein, AI131758 Protein, AND-34 Protein, BCAR3 Protein, breast cancer anti-estrogen resistance 3 Protein, breast cancer anti-estrogen resistance 3 L homeolog Protein, BCAR3 Protein, Bcar3 Protein, bcar3 Protein, bcar3.L Protein
- Background
- Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
- 92.4 kDa
- NCBI Accession
- NP_003558
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