BCL2A1 Protein (Transcript Variant 2)

Catalog No. ABIN2715200

Product Details

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 2

Origin: Human

Source: Escherichia coli (E. coli)

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human Bcl-2-like 5 (transcript variant 2) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Purity: > 95 % as determined by SDS-PAGE and Coomassie blue staining

Endotoxin Level: < 0.1 EU per μg protein as determined by LAL test

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 20 mM Phosphate buffer, 150 mM NaCl, 1 mM EDTA, 1 mM DTT, 10 % Glycerol, pH 7.4. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Alternative Name: Bcl-2-Like 5 (BCL2A1 Products)

Synonyms: ACC-1 Protein, ACC-2 Protein, BCL2L5 Protein, BFL1 Protein, GRS Protein, HBPA1 Protein, Bcl2a1d Protein, BCL2A1 Protein, BCL2 related protein A1 Protein, BCL2-related protein A1 Protein, BCL2A1 Protein, Bcl2a1 Protein

Background: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 18.5 kDa

NCBI Accession: NP_001108207