Doublecortin Protein (DCX) (Transcript Variant 5) (Myc-DYKDDDDK Tag)
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- Target See all Doublecortin (DCX) Proteins
- Doublecortin (DCX)
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 5
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Doublecortin protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Doublecortin (DCX), transcript variant 5. (transcript variant 5) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product DCX Protein
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Doublecortin (DCX) (AA 1-360) protein (GST tag)
DCX Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Doublecortin (DCX) (AA 107-208) protein (His-IF2DI Tag)DCX Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Doublecortin (DCX) (AA 1-365) protein (Strep Tag)Crystallography grade DCX Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Doublecortin (DCX) (AA 1-366) protein (Strep Tag)Crystallography grade DCX Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Doublecortin (DCX) (AA 1-361), (full length) protein (His tag)DCX Origin: Chicken Host: Escherichia coli (E. coli) Recombinant 90 % SDS, ELISA
Doublecortin (DCX) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)DCX Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- Doublecortin (DCX)
- Abstract
- DCX Products
- Synonyms
- DCX Protein, DBCN Protein, DC Protein, LISX Protein, SCLH Protein, XLIS Protein, Dbct Protein, 18C15.5 Protein, doublecortin Protein, DCX Protein, Dcx Protein
- Background
- This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
- 41.1
- NCBI Accession
- NP_001182482
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