DR1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2719757

Product Details

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This DR1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human DR1 / NC2-beta protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Alternative Name: Dr1,nc2-beta (DR1 Products)

Synonyms: BG:DS00929.3 Protein, CG4185 Protein, Dmel\\CG4185 Protein, Dr1 Protein, NC2 beta Protein, Nc2b Protein, dDr1 Protein, dNC2 Protein, wu:fj15f04 Protein, zgc:152914 Protein, 1700121L09Rik Protein, Dr1l Protein, NC2 Protein, NC2beta Protein, NC2-BETA Protein, Negative Cofactor 2beta Protein, TATA-BINDING PROTEIN-ASSOCIATED PHOSPHOPROTEIN Protein, TATA-binding protein-associated phosphoprotein Protein, putative tata-binding protein-associated phosphoprotein Protein, down-regulator of transcription 1 Protein, down-regulator of transcription 1, TBP-binding (negative cofactor 2) Protein, NC2beta Protein, ECU11_0730 Protein, EDI_229030 Protein, PTRG_08168 Protein, Smp_160150 Protein, EBI_26279 Protein, EBI_23074 Protein, VDBG_02216 Protein, dr1 Protein, Dr1 Protein, DR1 Protein

Background: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Molecular Weight: 19.3 kDa

NCBI Accession: NP_001929