DUSP12 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2719827

Product Details

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This DUSP12 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human DUSP12 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Alternative Name: Dusp12 (DUSP12 Products)

Synonyms: DUSP12 Protein, dusp12 Protein, zgc:114069 Protein, MGC154526 Protein, DUSP1 Protein, YVH1 Protein, 1190004O14Rik Protein, AA027408 Protein, AW049275 Protein, ESTM36 Protein, LMW-DSP4 Protein, T-DSP4 Protein, VH1 Protein, mVH1 Protein, GKAP Protein, dual specificity phosphatase 12 Protein, dual specificity phosphatase 12 L homeolog Protein, Dual specificity protein phosphatase 12 Protein, dual specificity protein phosphatase 12 Protein, DUSP12 Protein, dusp12 Protein, dusp12.L Protein, GL50803_36315 Protein, MGYG_01770 Protein, Dusp12 Protein

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Molecular Weight: 37.5 kDa

NCBI Accession: NP_009171

Pathways: Regulation of Carbohydrate Metabolic Process