Filamin A Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2721188

Product Details

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Filamin A protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human Filamin-A (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Henkels, Mallets, Dennis, Gomez-Cambronero: "S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 4, pp. 1299-313, (2015) (PubMed).

Target Details

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Alternative Name: Filamin-A (FLNA Products)

Synonyms: ABP-280 Protein, ABPX Protein, CSBS Protein, CVD1 Protein, FLN Protein, FLN-A Protein, FLN1 Protein, FMD Protein, MNS Protein, NHBP Protein, OPD Protein, OPD1 Protein, OPD2 Protein, XLVD Protein, XMVD Protein, fb98b06 Protein, wu:fb98b06 Protein, wu:fd09g03 Protein, wu:fd49a06 Protein, Dilp2 Protein, F730004A14Rik Protein, Fln1 Protein, filamin-1 Protein, RGD1560614 Protein, MGC147094 Protein, CG3937 Protein, Cher Protein, Dmel\\CG3937 Protein, Fil Protein, joy Protein, sko Protein, filamin A Protein, filamin A, alpha (actin binding protein 280) Protein, filamin, alpha Protein, filamin-A Protein, cheerio Protein, FLNA Protein, flna Protein, Flna Protein, LOC587317 Protein, cher Protein, LOC100380643 Protein

Background: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009].

Molecular Weight: 280.6 kDa

NCBI Accession: NP_001104026

Pathways: TCR Signaling, Maintenance of Protein Location