GPT2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2722205

Product Details

Target: GPT2 (Glutamic Pyruvate Transaminase (Alanine Aminotransferase) 2 (GPT2))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This GPT2 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human GPT2 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Target Details

Target: GPT2 (Glutamic Pyruvate Transaminase (Alanine Aminotransferase) 2 (GPT2))

Alternative Name: Gpt2 (GPT2 Products)

Synonyms: ALT2 Protein, GPT2 Protein, im:7150662 Protein, sb:cb580 Protein, zgc:165657 Protein, Cc2-5 Protein, 4631422C05Rik Protein, AU014768 Protein, AU041193 Protein, C87201 Protein, ALANINE AMINOTRANSFERASE 2 Protein, AtAlaAT2 Protein, AtAlaATm Protein, T10D10.20 Protein, T10D10_20 Protein, alanine aminotransferase 2 Protein, glutamic--pyruvic transaminase 2 Protein, glutamic pyruvate transaminase (alanine aminotransferase) 2 L homeolog Protein, glutamic pyruvate transaminase (alanine aminotransferase) 2 Protein, alanine aminotransferase 2 Protein, GPT2 Protein, gpt2.L Protein, gpt2 Protein, PTRG_06494 Protein, Gpt2 Protein, ALAAT2 Protein

Background: This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants.

Molecular Weight: 57.7 kDa

NCBI Accession: NP_597700