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GCH1 Protein (His tag)

GCH1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2722329
  • Target See all GCH1 Proteins
    GCH1 (GTP Cyclohydrolase 1 (GCH1))
    Protein Type
    Recombinant
    Origin
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 5
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This GCH1 protein is labelled with His tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human GTP cyclohydrolase 1 (GCH1) (full length, N-term HIS tag, transcript variant 2) protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product GCH1 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the N-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    GCH1 (GTP Cyclohydrolase 1 (GCH1))
    Abstract
    GCH1 Products
    Synonyms
    DYT14 Protein, DYT5 Protein, DYT5a Protein, GCH Protein, GTP-CH-1 Protein, GTPCH1 Protein, HPABH4B Protein, GTP-CH Protein, GTPCH Protein, Gch Protein, MGC89622 Protein, gch1a Protein, wu:fc16b10 Protein, zgc:195269 Protein, GTP cyclohydrolase 1 Protein, GTP cyclohydrolase 1-like Protein, GCH1 Protein, Gch1 Protein, gch1 Protein, Weevi_1190 Protein, Halhy_0838 Protein, Sinme_1220 Protein, Sphch_1077 Protein, LOC100136794 Protein
    Background
    This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described however, not all variants give rise to a functional enzyme.
    Molecular Weight
    27.7 kDa
    NCBI Accession
    NP_001019195
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