ING3 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2723448

Product Details

Target: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This ING3 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human ING3 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Alternative Name: Ing3 (ING3 Products)

Synonyms: ING3 Protein, Eaf4 Protein, ING2 Protein, MEAF4 Protein, p47ING3 Protein, 1300013A07Rik Protein, P47ING3 Protein, zgc:56327 Protein, inhibitor of growth family member 3 Protein, inhibitor of growth family, member 3 Protein, inhibitor of growth protein 3 Protein, inhibitor of growth family member 3 L homeolog Protein, ING3 Protein, Ing3 Protein, CpipJ_CPIJ009396 Protein, ing3 Protein, ing3.L Protein

Background: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

Molecular Weight: 46.6 kDa

NCBI Accession: NP_061944