MAPK8IP1 Protein (Myc-DYKDDDDK Tag)
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- Target See all MAPK8IP1 Proteins
- MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This MAPK8IP1 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human MAPK8IP1 / JIP1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product MAPK8IP1 Protein
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Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (AA 1-711) protein (Strep Tag)
Crystallography grade MAPK8IP1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (AA 1-707) protein (Strep Tag)Crystallography grade MAPK8IP1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))
- Alternative Name
- Mapk8ip1,jip1 (MAPK8IP1 Products)
- Synonyms
- IB1 Protein, JIP-1 Protein, Jip1 Protein, Prkm8ip Protein, Skip Protein, mjip-2a Protein, JIP1 Protein, Jip-1 Protein, Mapk8ip Protein, PRKM8IP Protein, mitogen-activated protein kinase 8 interacting protein 1 Protein, MAPK8IP1 Protein, Mapk8ip1 Protein
- Background
- This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
- Molecular Weight
- 77.3 kDa
- NCBI Accession
- NP_005447
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