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MBNL1 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

MBNL1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2725582
  • Target See all MBNL1 Proteins
    MBNL1 (Muscleblind-like Protein 1 (MBNL1))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 3
    Origin
    • 8
    • 1
    Human
    Source
    • 4
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This MBNL1 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human MBNL1 (transcript variant 3) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product MBNL1 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    MBNL1 (Muscleblind-like Protein 1 (MBNL1))
    Alternative Name
    Mbnl1 (MBNL1 Products)
    Synonyms
    MBNL1 Protein, zgc:153954 Protein, Mbnl Protein, mKIAA0428 Protein, EXP Protein, EXP35 Protein, EXP40 Protein, EXP42 Protein, MBNL Protein, muscleblind like splicing regulator 1 Protein, muscleblind-like splicing regulator 1 Protein, muscleblind like splicing factor 1 Protein, MBNL1 Protein, mbnl1 Protein, Mbnl1 Protein
    Background
    This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.
    Molecular Weight
    41.6 kDa
    NCBI Accession
    NP_997176
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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