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CCL18 Protein

CCL18 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
Catalog No. ABIN2726055
  • Target See all CCL18 Proteins
    CCL18 (Chemokine (C-C Motif) Ligand 18 (Pulmonary and Activation-Regulated) (CCL18))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 13
    • 1
    Human
    Source
    • 8
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Application
    Functional Studies (Func), Antibody Production (AbP), Standard (STD), Protein Interaction (PI)
    Specificity
    Optimal preservation of protein structure, post-translational modifications and functions.
    Characteristics
    • Recombinant human MIP4 / CCL18 protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.
    Purity
    > 95 % as determined by SDS-PAGE and Coomassie blue staining
    Endotoxin Level
    Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
    Biological Activity Comment
    Assay #1: Determined by its ability to chemoattract human T lymphocytes using a concentration of 1.0-10.0 ng/ml. Assay #2: Determined by its ability to chemoattract human iDCs using a concentration of 1.0-10.0 ng/ml.
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    Discover our top product CCL18 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Restrictions
    For Research Use only
  • Buffer
    Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
    Handling Advice
    Resuspend the protein in the desired concentration in proper buffer
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    CCL18 (Chemokine (C-C Motif) Ligand 18 (Pulmonary and Activation-Regulated) (CCL18))
    Alternative Name
    Mip4,ccl18 (CCL18 Products)
    Synonyms
    H7AP1 Protein, PARC Protein, RP3-330M21.2 Protein, AMAC-1 Protein, AMAC1 Protein, CKb7 Protein, DC-CK1 Protein, DCCK1 Protein, MIP-4 Protein, SCYA18 Protein, cullin 9 Protein, C-C motif chemokine ligand 18 Protein, CUL9 Protein, CCL18 Protein
    Background
    This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.
    Molecular Weight
    7.8 kDa
    NCBI Accession
    NP_002979
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