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NANS Protein (Myc-DYKDDDDK Tag)

NANS Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2726801
  • Target See all NANS Proteins
    NANS (N-Acetylneuraminic Acid Synthase (NANS))
    Protein Type
    Recombinant
    Origin
    Human
    Source
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This NANS protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human NANS protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product NANS Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • van Karnebeek, Bonafé, Wen, Tarailo-Graovac, Balzano, Royer-Bertrand, Ashikov, Garavelli, Mammi, Turolla, Breen, Donnai, Cormier, Heron, Nishimura, Uchikawa, Campos-Xavier, Rossi, Hennet et al.: "NANS-mediated synthesis of sialic acid is required for brain and skeletal development. ..." in: Nature genetics, Vol. 48, Issue 7, pp. 777-84, (2016) (PubMed).

  • Target
    NANS (N-Acetylneuraminic Acid Synthase (NANS))
    Alternative Name
    Nans (NANS Products)
    Synonyms
    MGC84329 Protein, SAS Protein, N-acetylneuraminate synthase L homeolog Protein, N-acetylneuraminate synthase Protein, nans.L Protein, NANS Protein, Nans Protein
    Background
    Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. [UniProtKB/Swiss-Prot Function]
    Molecular Weight
    40.1 kDa
    NCBI Accession
    NP_061819
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