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DCC Protein (Myc-DYKDDDDK Tag)

DCC Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2727109
  • Target See all DCC Proteins
    DCC (Deleted in Colorectal Carcinoma (DCC))
    Protein Type
    Recombinant
    Origin
    • 7
    • 4
    • 1
    Human
    Source
    • 6
    • 2
    • 2
    HEK-293 Cells
    Purification tag / Conjugate
    This DCC protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Netrin receptor DCC protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product DCC Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    DCC (Deleted in Colorectal Carcinoma (DCC))
    Alternative Name
    Netrin Receptor Dcc (DCC Products)
    Synonyms
    CRC18 Protein, CRCR1 Protein, IGDCC1 Protein, MRMV1 Protein, DCC Protein, zdcc Protein, C030036D22Rik Protein, Igdcc1 Protein, xdcc Protein, XDCCa Protein, dcca-A Protein, Dcc Protein, DCC netrin 1 receptor Protein, deleted in colorectal carcinoma Protein, netrin receptor DCC Protein, DCC Protein, dcc Protein, Dcc Protein, LOC100712666 Protein
    Background
    This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
    Molecular Weight
    158.3 kDa
    NCBI Accession
    NP_005206
    Pathways
    Regulation of Cell Size
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