DCC Protein (Myc-DYKDDDDK Tag)
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- Target See all DCC Proteins
- DCC (Deleted in Colorectal Carcinoma (DCC))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This DCC protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Netrin receptor DCC protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product DCC Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- DCC (Deleted in Colorectal Carcinoma (DCC))
- Alternative Name
- Netrin Receptor Dcc (DCC Products)
- Synonyms
- CRC18 Protein, CRCR1 Protein, IGDCC1 Protein, MRMV1 Protein, DCC Protein, zdcc Protein, C030036D22Rik Protein, Igdcc1 Protein, xdcc Protein, XDCCa Protein, dcca-A Protein, Dcc Protein, DCC netrin 1 receptor Protein, deleted in colorectal carcinoma Protein, netrin receptor DCC Protein, DCC Protein, dcc Protein, Dcc Protein, LOC100712666 Protein
- Background
- This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
- Molecular Weight
- 158.3 kDa
- NCBI Accession
- NP_005206
- Pathways
- Regulation of Cell Size
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