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NSMCE2 Protein (His tag)

NSMCE2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2727651
  • Target See all NSMCE2 Proteins
    NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
    Protein Type
    Recombinant
    Origin
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 4
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This NSMCE2 protein is labelled with His tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human NSMCE2 (full length, N-term HIS tag) protein expressed in E.coli.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product NSMCE2 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the N-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
    Alternative Name
    Nsmce2 (NSMCE2 Products)
    Synonyms
    1110014D18Rik Protein, AI661537 Protein, RGD1305156 Protein, C8orf36 Protein, MMS21 Protein, NSE2 Protein, ZMIZ7 Protein, Non-SMC element 2 Protein, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase Protein, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog Protein, Smc5-6 complex non-SMC subunit 2 Protein, Nsmce2 Protein, NSMCE2 Protein, nsmce2.L Protein, nse2 Protein
    Background
    This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance.
    Molecular Weight
    27.8 kDa
    NCBI Accession
    NP_775956
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