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PANK2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

PANK2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2728205
  • Target See all PANK2 Proteins
    PANK2 (Pantothenate Kinase 2 (PANK2))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 1
    Origin
    • 3
    • 1
    Human
    Source
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This PANK2 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human PANK2 (transcript variant 1) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product PANK2 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    PANK2 (Pantothenate Kinase 2 (PANK2))
    Alternative Name
    Pank2 (PANK2 Products)
    Synonyms
    ATPANK2 Protein, F10M6.180 Protein, F10M6_180 Protein, pantothenate kinase 2 Protein, PANK2 Protein, C20orf48 Protein, HARP Protein, HSS Protein, NBIA1 Protein, PKAN Protein, 4933409I19Rik Protein, AI642621 Protein, pantothenate kinase 2 Protein, pantothenate kinase 2, mitochondrial Protein, ribonuclease A family member 11 (inactive) Protein, PANK2 Protein, Tsp_01576 Protein, LOC100539295 Protein, Pank2 Protein, RNASE11 Protein
    Background
    This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.
    Molecular Weight
    59.1 kDa
    NCBI Accession
    NP_705902
    Pathways
    Ribonucleoside Biosynthetic Process
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