PDE4A Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2728507

Product Details

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 4

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PDE4A protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human PDE4A (transcript variant 4) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Taniguchi, Iizumi, Watanabe, Masuda, Morita, Aono, Toriyama, Oishi, Goi, Sakai: "Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer." in: Cell death & disease, Vol. 7, pp. e2211, (2016) (PubMed).

Target Details

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Alternative Name: Pde4a (PDE4A Products)

Synonyms: pde4 Protein, dpde2 Protein, pde46 Protein, PDE4A Protein, Pde4a Protein, D9Ertd60e Protein, Dpde2 Protein, DPDE2 Protein, PDE4 Protein, PDE46 Protein, PHOSA Protein, phosphodiesterase 4A S homeolog Protein, phosphodiesterase 4A, cAMP-specific Protein, phosphodiesterase 4A Protein, phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) Protein, cAMP-specific 3',5'-cyclic phosphodiesterase 4A Protein, phosphodiesterase 4A, cAMP specific Protein, phosphodiesterase 4C Protein, pde4a.S Protein, pde4a Protein, PDE4A Protein, LOC100009247 Protein, Pde4a Protein, PDE4C Protein

Background: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

Molecular Weight: 72 kDa

NCBI Accession: NP_006193

Pathways: cAMP Metabolic Process