PBX1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2729562

Product Details

Target: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PBX1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human Pre-B-cell leukemia homeobox 1 (PBX1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Alternative Name: Pre-B-Cell Leukemia Homeobox 1 (Pbx1) (PBX1 Products)

Synonyms: fi29e01 Protein, pbx1b Protein, wu:fi29e01 Protein, zgc:55265 Protein, 2310056B04Rik Protein, AI848790 Protein, AU015730 Protein, D230003C07Rik Protein, Pbx-1 Protein, Pbx1a Protein, Pbx1b Protein, PBX1A Protein, Xpbx1 Protein, Xpbx1b Protein, PBX homeobox 1 Protein, pre-B-cell leukemia homeobox 1a Protein, pre B cell leukemia homeobox 1 Protein, pre-B-cell leukemia homeobox 1 S homeolog Protein, PBX1 Protein, pbx1a Protein, Pbx1 Protein, pbx1.S Protein

Background: This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(119) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 46.4 kDa

NCBI Accession: NP_002576