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PCSK1 Protein (His tag)

PCSK1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2729761
  • Target See all PCSK1 Proteins
    PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
    Protein Type
    Recombinant
    Origin
    • 5
    • 3
    • 2
    Human
    Source
    • 4
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This PCSK1 protein is labelled with His tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Proprotein convertase subtilisin/kexin type 1 (PCSK1), transcript variant 3, full length, with N-terminal HIS tag, expressed in E. coli, 50 μg (full length, N-term HIS tag, transcript variant 3) protein expressed in E.coli.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product PCSK1 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the N-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
    Abstract
    PCSK1 Products
    Synonyms
    BMIQ12 Protein, NEC1 Protein, PC1 Protein, PC3 Protein, SPC3 Protein, Nec-1 Protein, Nec1 Protein, Phpp-1 Protein, BDP Protein, PC1/3 Protein, proprotein convertase subtilisin/kexin type 1 Protein, prohormone convertase 1 Protein, PCSK1 Protein, Pcsk1 Protein, pcsk1 Protein, PC1B Protein
    Background
    This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene
    Molecular Weight
    49.8 kDa
    NCBI Accession
    NP_001171347
    Pathways
    Peptide Hormone Metabolism
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