Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PPM1A Protein (Transcript Variant 1) (His tag)

PPM1A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2729792
  • Target See all PPM1A Proteins
    PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 1
    Origin
    • 6
    • 3
    • 2
    • 1
    • 1
    Human
    Source
    • 6
    • 3
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This PPM1A protein is labelled with His tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Protein phosphatase 1A / PPM1A (transcript variant 1) protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    Purity
    > 95 % as determined by SDS-PAGE and Coomassie blue staining
    Endotoxin Level
    < 0.1 EU per μg protein as determined by LAL test
    Top Product
    Discover our top product PPM1A Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the N-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    20 mM Phosphate buffer, 150 mM NaCl, pH 7.4. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
    Alternative Name
    Protein Phosphatase 1a,ppm1a (PPM1A Products)
    Synonyms
    PP2C-ALPHA Protein, PP2CA Protein, PP2Calpha Protein, pp2ca1 Protein, ppp1r13b Protein, si:ch211-253p18.1 Protein, wu:fd42g12 Protein, zgc:153820 Protein, 2310003C21Rik Protein, 2900017D14Rik Protein, AI427932 Protein, AU017636 Protein, MMPa-2 Protein, MPPa-1 Protein, Pp2c1 Protein, pp2c-alpha Protein, pp2ca Protein, pp2calpha Protein, pp2ca2 Protein, protein phosphatase, Mg2+/Mn2+ dependent 1A Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1Ab Protein, protein phosphatase 1A, magnesium dependent, alpha isoform Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1A Protein, protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1Aa Protein, PPM1A Protein, ppm1ab Protein, Ppm1a Protein, ppm1a.L Protein, ppm1aa Protein
    Background
    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
    Molecular Weight
    43.5 kDa
    NCBI Accession
    NP_066283
You are here:
Support