PSMC4 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2729969

Product Details

Target: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PSMC4 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human PSMC4 / TBP7 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Alternative Name: Psmc4,tbp7 (PSMC4 Products)

Synonyms: NCU02260.1 Protein, AO090003000692 Protein, DDBDRAFT_0188209 Protein, DDBDRAFT_0191435 Protein, DDB_0188209 Protein, DDB_0191435 Protein, MIP224 Protein, RPT3 Protein, S6 Protein, TBP-7 Protein, TBP7 Protein, CIP21 Protein, Tbp7 Protein, 26S protease regulatory subunit 6B Protein, regulatory particle, ATPase-like-3 Protein, 26S proteasome regulatory subunit 6B Protein, proteasome 26S subunit, ATPase 4 Protein, proteasome (prosome, macropain) 26S subunit, ATPase, 4 Protein, LOC732870 Protein, rpt-3 Protein, ATEG_04674 Protein, LELG_01296 Protein, HCAG_00039 Protein, LOC5568998 Protein, GL50803_7950 Protein, EDI_044950 Protein, AOR_1_1218154 Protein, PTRG_03339 Protein, psmC4 Protein, prs6b Protein, LOC100381342 Protein, psmc4 Protein, PSMC4 Protein, Psmc4 Protein

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson&aposs disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Molecular Weight: 47.2 kDa

NCBI Accession: NP_006494

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway