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SLC19A3 Protein (Myc-DYKDDDDK Tag)

Slc19a3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2732152
  • Target See all SLC19A3 (Slc19a3) Proteins
    SLC19A3 (Slc19a3) (Solute Carrier Family 19, Member 3 (Slc19a3))
    Protein Type
    Recombinant
    Origin
    • 2
    • 1
    Human
    Source
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This SLC19A3 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human SLC19A3 / THTR2 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product Slc19a3 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    SLC19A3 (Slc19a3) (Solute Carrier Family 19, Member 3 (Slc19a3))
    Alternative Name
    Slc19a3,thtr2 (Slc19a3 Products)
    Synonyms
    BBGD Protein, THMD2 Protein, THTR2 Protein, thtr2 Protein, MGC52872 Protein, MGC89434 Protein, si:dkey-223n17.4 Protein, slc19a3 Protein, A230084E24Rik Protein, AI788884 Protein, ThTr2 Protein, solute carrier family 19 member 3 Protein, solute carrier family 19 member 3 L homeolog Protein, solute carrier family 19 (thiamine transporter), member 3 Protein, thiamine transporter 2 Protein, solute carrier family 19 (thiamine transporter), member 3b Protein, solute carrier family 19, member 3 Protein, thiamine transporter 2-like Protein, SLC19A3 Protein, Slc19a3 Protein, slc19a3.L Protein, slc19a3 Protein, LOC486151 Protein, slc19a3b Protein, LOC100230080 Protein
    Background
    This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD) a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.[provided by RefSeq, Jan 2010].
    Molecular Weight
    55.5 kDa
    NCBI Accession
    NP_079519
    Pathways
    Dicarboxylic Acid Transport
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