STIM1 Protein (Myc-DYKDDDDK Tag)
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- Target See all STIM1 Proteins
- STIM1 (Stromal Interaction Molecule 1 (STIM1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This STIM1 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human STIM1 / GOK protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product STIM1 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- STIM1 (Stromal Interaction Molecule 1 (STIM1))
- Alternative Name
- Stim1,gok (STIM1 Products)
- Synonyms
- stim1 Protein, MGC76045 Protein, STIM1 Protein, si:dkey-24p1.5 Protein, MGC154748 Protein, si:ch211-112l17.2 Protein, Stim1 Protein, D11S4896E Protein, GOK Protein, TAM Protein, SIM Protein, stromal interaction molecule 1 Protein, stromal interaction molecule 1a Protein, stromal interaction molecule 1 L homeolog Protein, stromal interaction molecule 1b Protein, STIM1 Protein, stim1 Protein, stim1a Protein, stim1.L Protein, stim1b Protein, Stim1 Protein
- Background
- This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3&apos end of this gene situated 1.6 kb from the 5&apos end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
- Molecular Weight
- 74.8 kDa
- NCBI Accession
- NP_003147
- Pathways
- TCR Signaling, BCR Signaling
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