Apolipoprotein A-I (APOA1) Protein

Details for Product No. ABIN413012, Supplier: Log in to see
Protein Name
  • APOA1
  • MGC64335
  • MGC89745
  • apoa-i
  • ApoA-I
  • LOC100136573
  • apoa1
  • Alp-1
  • Apoa-1
  • Brp-14
  • Ltw-1
  • Lvtw-1
  • Sep-1
  • Sep-2
  • Sep2
  • apoA-I
  • Apo-AI
  • ApoAI
  • apoa
  • cb49
  • wu:fb33f01
  • zgc:103718
  • apolipoprotein A-I
  • apolipoprotein A-I-like
  • apolipoprotein A-Ia
  • APOA1
  • LOC100386212
  • apoa1
  • apoa-i
  • LOC100136573
  • Apoa1
  • APOAI
  • apoa1a
Origin
Human
56
7
5
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Source
Escherichia coli (E. coli)
33
24
17
4
3
3
2
1
1
1
Protein Type
Recombinant
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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Purity ≥97 % by SDS-PAGE
Sterility Sterile filtered
Endotoxin Level <0.1 ng/μg
Background ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This apoA-I ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the "good cholesterol." The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano). The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic Vascular diseases. Recombinant human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.

Alternative Names: APOA1, MGC117399, Apoa1, Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, apolipoprotein, apolipoproteins, MGC102525, Sep-1, Sep-2, Sep2, Human ApoA-1, ApoA-1, ApoA1, Apo A1, h-ApoA-1, rh-ApoA-1, recombinant human ApoA-1, ApoA1,recombinant ApoA-1, Apo, ApoA1, Apolipoprotein A-I, Apolipoprotein AI, Apolipoprotein
Molecular Weight 28.2 kDa
Gene ID 335
NCBI Accession NM_000039
Pathways Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and store at 4 °C for 1 week or -20 °C for future use.
Buffer Sterile filtered and lyophilized with no additives
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for Apolipoprotein A-I (APOA1) Protein (ABIN413012) Apolipoprotein A-I (APOA1) protein
Product cited in: de Haan, Karasinska, Ruddle, Hayden: "Hepatic ABCA1 expression improves β-cell function and glucose tolerance." in: Diabetes, Vol. 63, Issue 12, pp. 4076-82, 2014 (PubMed).

Saeed, Otsuka, Polavarapu, Karmali, Weiss, Davis, Rostad, Pachura, Adams, Elliott, Taylor, Narula, Kolodgie, Virmani, Hong, Finn: "Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 32, Issue 2, pp. 299-307, 2012 (PubMed).

Barlic, Zhu, Murphy: "Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 7928-36, 2009 (PubMed).