Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) Protein

Name: Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C)

Synonyms: BAFFR, CD268, BAFF-R, MGC138235, RGD1560810, TNFRSF13C

Protein Type: Recombinant

Source: Escherichia Coli (E. coli)

Origin (Gene): Human

Application: Western Blotting (WB), ELISA, Functional Studies (Func)

Catalog no.: ABIN413048

Additional Information

Characteristics: Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED 50 for this effect is typically 1-5 μ g/ml in the presence of 1 μ g/ml human soluble BAFF.

Description: BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFFR/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFFR is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFFR protein.

Molecular Weight: 7.7 kDa

Application Details

Purity: >95% by SDS-PAGE and HPLC analyses Endotoxin level is <0.1 ng per μ g of BAFF-R.

Buffer: Sterile filtered and lyophilized from a solution (1 mg/ml) containing 20 mM phosphate buffer, pH 8.0, and 500 mM NaCl.

Storage: The lyophilized BAFF-R is best-stored desiccated below 0 °C. Reconstituted human BAFF-R should be stored in working aliquots at -20 °C. Reconstitution: Centrifuge the vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4 °C for 1 week or –20 °C for future use.

Restrictions: For Research Use only