Bone Morphogenetic Protein 6 (BMP6) (Active) Protein

Details for Product No. ABIN413091
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Protein Name
Synonyms BMP6, zgc:113595, vgr, vgr-1, vgr1, VGR, VGR1, D13Wsu115e, Vgr1
(27), (3), (1)
Escherichia coli (E. coli)
(18), (5), (3), (2), (2), (1)
Protein Type Recombinant
Biological Activity Active
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
Pubmed 2 references available
Quantity 1 mg
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Availability Will be delivered in 2 to 3 Business Days
Characteristics Biological Activity: recombinant human BMP-6 is biologically active. The ED₅₀ as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 μg/mL.
Purity ≥98 %
Sterility Sterile filtered
Endotoxin Level <0.1 ng/μg
Alternative Name BMP-6
Background BMPs (bone morphogenetic proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Recombinant human BMP-6 produced from E. coli contains a mixture of monomer (15 kDa), dimer (30 kDa), and multimers. The dimer is an active polypeptide chain containing 2X142 amino acid residues.
Synonyms: Human BMP-6, BMP-6, BMP6, BMP 6, h-BMP-6, rh-BMP-6, recombinant human BMP-6, recombinant BMP-6, BMP, VGR, VGR1, BMP-6
Molecular Weight monomer (15 kDa), dimer (30 kDa)
Gene ID 654
UniProt P22004
Research Area Signaling
Application Notes Optimal working dilution should be determined by the investigator.

physical form description: Sterile filtered and lyophilized with no additives

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute to a concentration of 0.1-1.0 mg/mL in sterile 20 mM acetic acid. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
Buffer Lyophilized with no additives
Preservative Without preservative
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Crews, Adame, Patrick et al.: "Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 37, pp. 12252-62, 2010 (PubMed).

Jukes, Both, Leusink et al.: "Endochondral bone tissue engineering using embryonic stem cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 19, pp. 6840-5, 2008 (PubMed).

Catalog No. ABIN413091
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