Bone Morphogenetic Protein 6 (BMP6) (Active) Protein

Details for Product No. ABIN413091, Supplier: Log in to see
Protein Name
  • BMP6
  • zgc:113595
  • vgr
  • vgr-1
  • vgr1
  • VGR
  • VGR1
  • D13Wsu115e
  • Vgr1
  • bone morphogenetic protein 6
  • BMP6
  • bmp6
  • Bmp6
  • LOC100354948
Origin
Human
21
2
1
Source
Escherichia coli (E. coli)
13
4
3
2
1
1
Protein Type
Recombinant
Biological Activity
Active
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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Characteristics Molecule Information: monomer (15 kDa), dimer (30 kDa)
Purity ≥98 % by SDS-PAGE
≥98 % by HPLC
Sterility Sterile filtered
Endotoxin Level <0.1 ng/μg
ProductDetails: Biological Activity Comment recombinant human BMP-6 is biologically active. The ED₅₀ as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 μg/ml.
Background BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Recombinant human BMP-6 produced from E. coli contains a mixture of monomer (15 kDa), dimer (30 kDa), and multimers. The dimer is an active polypeptide chain containing 2X142 amino acid residues.

Alternative Names: VGR, VGR1, BMP-6, VG-1-related protein
Gene ID 654
UniProt P22004
Research Area Stem Cells, Signaling, Extracellular Matrix
Pathways Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute to a concentration of 0.1-1.0 mg/mL in sterile 20 mM acetic acid. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
Buffer Sterile filtered and lyophilized with no additives
Preservative Without preservative
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Crews, Adame, Patrick, Delaney, Pham, Rockenstein, Hansen, Masliah: "Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 37, pp. 12252-62, 2010 (PubMed).

Jukes, Both, Leusink, Sterk, van Blitterswijk, de Boer: "Endochondral bone tissue engineering using embryonic stem cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 19, pp. 6840-5, 2008 (PubMed).