Collagen, Type XVIII, alpha 1 (COL18A1) Protein

Name: Collagen, Type XVIII, alpha 1 (COL18A1)

Synonyms: KNO, KNO1, FLJ27325, FLJ34914, MGC74745, kno, MGC76284, COL18A1, MGC140499, endostatin, cb371, cb529, fc96d06, sb:cb529, wu:fb47h10, wu:fb77g12, wu:fc50f04, wu:fc96d06, wu:fk02h12

Protein Type: Recombinant

Source: Methylotrophic Yeast (Pichia pastoris)

Origin (Gene): Human

Application: Western Blotting (WB), ELISA, Functional Studies (Func)

Catalog no.: ABIN413195

Additional Information

Characteristics: BioVision’s human Endostatin is biologically active when compared to standards. The activity as calculated by ECE migration inhibition was found to be 50,000 IU/mg.

Description: Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.

Molecular Weight: 20 kDa

Application Details

Purity: > 98% as determined by SDS-PAGE and HPLC. Endotoxin level is less than 0.1 ng/mg of Endostatin PHYSICAL

Storage: Stable at 4 °C for 2-4 weeks. For long-term storage, aliquot and keep desiccated below –20 °C. Avoid freeze-thaw cycles.

Restrictions: For Research Use only