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Follistatin (FST) (Active) Protein

Details for Product No. ABIN413281
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Protein Name
Synonyms CG12955, CG12956, CG33466, Dmel\\CG33466, Fol1, dFS, dFol1, dfs, fs, FS, foll, xfs, FST, fst, AL033346, FOL1, Fst-288, RATFOL1, cb446, fd07h10, fst1, wu:fd07h10
Origin
Human
(34), (8), (1), (1), (1), (1), (1), (1)
Source
Escherichia coli (E. coli)
(24), (8), (3), (2), (1)
Protein Type Recombinant
Biological Activity Active
Application
Western Blotting (WB), ELISA, Functional Studies (Func)
Pubmed 3 references available
Quantity 50 µg
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Catalog No. ABIN413281
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Specificity Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.1-0.4 µg/mL in the presence of 7.5 ng/mL Activin A. Results: 0.1-0.4 µg/mL.
Characteristics Biological activity: 0.1-0.4 µg/mL Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.1-0.4 µg/mL in the presence of 7.5 ng/mL Activin A.
Purity > 95 % by SDS-PAGE
Sterility Sterile filtered
Endotoxin Level < 0.1 ng/μg
Alternative Name Follistatin
Background Follistatin belongs to a group of structurally-diverse diffusible proteins that binds to TGF-beta ligands and inhibit their activity by hindering access to signaling receptors. This naturally occurring antagonist binds to Activin, BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids including 36 cysteine residues.
Synonyms: Human Follistatin, Follistatin, h-Follistatin, rh-Follistatin, recombinant human Follistatin, recombinant Follistatin, Follistatin, FST, FS, Activin-binding protein
Molecular Weight 31.5 kDa
Gene ID 10468
UniProt P19883
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Hormones, Stem Cells, Proliferation, Signaling, Enzymes
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in H2O to a concentration of 0.1-1.0 µg/µL. The solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
Buffer 10 mM Sodium Phosphate, pH 7.5 + 75 mM NaCl
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Rose, Mattis, Rindt et al.: "Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy." in: Human molecular genetics, Vol. 18, Issue 6, pp. 997-1005, 2009 (PubMed).

Umezu, Yamanouchi, Iida et al.: "Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 10, pp. 4601-6, 2010 (PubMed).

Li, Shimono, Norioka et al.: "Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate binding activity." in: The Journal of biological chemistry, Vol. 285, Issue 47, pp. 36645-55, 2010 (PubMed).

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