Ghrelin/obestatin Prepropeptide (GHRL) (Active) Protein

Details for Product No. ABIN413323, Supplier: Log in to see
Protein Name
  • 2210006E23Rik
  • Ghr
  • MTLRP
  • MTLRPAP
  • m46
  • Gh1-1
  • GRHL
  • MTLRP-AP
  • GHR
  • ghrelin
  • ghrelin-like
  • ghrelin/obestatin preprohormone
  • ghrelin/obestatin prepropeptide
  • Ghrl
  • LOC100349547
  • ghrl
  • GHRL
Origin
Human
14
1
Source
Escherichia coli (E. coli)
8
2
1
1
1
Protein Type
Native
Biological Activity
Active
Application
Functional Studies (Func), SDS-PAGE (SDS), Western Blotting (WB)
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Purpose Pure human Gherlin for use in ELISA, as a positive control in Western blot analysis, or as a blocking peptide to block antibody activity..
Sequence GS(X)FLSPEHQRVQ QRKESKKPPA KLQPR X = serine modified with n-octanoic acid
Background Ghrelin ('ghre' is the Proto-Indo-European root of the word 'grow') has been identified as the endogenous ligand for the GHS-R (growth hormone secretagogues receptor). Ghrelin is expressed in the stomach, small and large intestines, and brain regions that are involved in the regulation of food intake. Both ghrelin and GHS-R expression is also detected in the heart, suggesting that Ghrelin might have some cardiovascular effects. Ghrelin administration stimulates GH secretion but also causes weight gain by increase food intake. Mature human and rat Ghrelin (28 a.a.) are produced from a 117 amino acid precursor. Ghrelin has an unusual modification at Ser3 residue that is n-octanoylated and is essential for biological activity. Ghrelin is the first known example of a bioactive peptide modified by an acyl acid
Alternate Names: Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46Human Ghrelin (Ser3 modified), Ghrelin, h-Ghrelin, rh-Ghrelin, recombinant human Ghrelin, Ghrelin (Ser3 modified), recombinant Ghrelin, Ghrelin
Molecular Weight 3.374 kDa
Gene ID 51738
UniProt Q9UBU3
Research Area Cardiovascular, Atherosclerosis, Hormones
Pathways Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Activity Specification: Biological activity of ghrelin has not been established. The peptide can be used in ELISA, as a positive control in Western blot analysis, or as a blocking peptide to block antibody activity.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in PBS containing at least 0.1 % BSA to a concentration of 1.0 mg/mL.
Buffer Lyophilized peptide
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Storage Comment -20°C
Expiry Date 12 months
Product cited in: Iantorno, Chen, Kim, Tesauro, Lauro, Cardillo, Quon: "Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells." in: American journal of physiology. Endocrinology and metabolism, Vol. 292, Issue 3, pp. E756-64, 2007 (PubMed).

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