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Interleukin 17A (IL17A) (Active) Protein

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Protein Name
Synonyms Il17, IL17A, CTLA8, IL-17, IL-17A, IL17, Ctla-8, Ctla8, CTLA-8, ChIL-17, IL-17F
(57), (33), (13), (6), (4), (3), (2), (1), (1), (1), (1)
Escherichia coli (E. coli)
(85), (5), (4), (4), (2), (1), (1), (1), (1)
Protein Type Recombinant
Biological Activity Active
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
Pubmed 3 references available
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Quantity 1 mg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Characteristics 31.0 kDa
Biological Activity: The ED₅₀ as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts is < 2 ng/mL, corresponding to a specific activity of > 5 x 10⁵ units/mg.
Purity ≥98 %
Sterility Sterile filtered
Endotoxin Level <0.1 ng/μg
Background The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intraCellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Recombinant IL-17 is a 31 kDa disulfide-linked homodier of two 136 amino acid polypeptide chains.
Synonyms: Human IL-17A, IL-17A, IL17A, IL 17 A, h-IL-17A, rh-IL-17A, recombinant human IL-17A, recombinant IL-17, IL, interluekin, IL17A/F, IL17 A/F, IL-17A/F Interleukin-17 A/F, Interleukin-17 AF
Molecular Weight 31.0 kDa
Gene ID 3605
UniProt Q16552
Pathways TCR Signaling
Application Notes Optimal working dilution should be determined by the investigator.

physical form description: Sterile filtered and lyophilized with no additives

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
Buffer Lyophilized with no additives
Preservative Without preservative
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Trinité, Ohlson, Voznesensky et al.: "An HIV-1 replication pathway utilizing reverse transcription products that fail to integrate." in: Journal of virology, Vol. 87, Issue 23, pp. 12701-20, 2013 (PubMed).

Bérubé, Roussel, Nattagh et al.: "Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ..." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22299-307, 2010 (PubMed).

Roussel, Houle, Chan et al.: "IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 8, pp. 4531-7, 2010 (PubMed).

Catalog No. ABIN413453
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