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Interleukin 17A (IL17A) (Active) Protein

Details for Product No. ABIN413453, Supplier: Login to see
Protein Name
  • Il17
  • IL17A
  • CTLA8
  • IL-17
  • IL-17A
  • IL17
  • Ctla-8
  • Ctla8
  • CTLA-8
  • ChIL-17
  • IL-17F
Origin
Human
58
34
13
6
4
3
2
1
1
1
1
Source
Escherichia coli (E. coli)
86
6
5
3
2
1
1
1
1
Protein Type
Recombinant
Biological Activity
Active
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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Characteristics 31.0 kDa
Biological Activity: The ED₅₀ as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts is < 2 ng/mL, corresponding to a specific activity of > 5 x 10⁵ units/mg.
Purity ≥98 %
Sterility Sterile filtered
Endotoxin Level <0.1 ng/μg
Background The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intraCellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Recombinant IL-17 is a 31 kDa disulfide-linked homodier of two 136 amino acid polypeptide chains.
Synonyms: Human IL-17A, IL-17A, IL17A, IL 17 A, h-IL-17A, rh-IL-17A, recombinant human IL-17A, recombinant IL-17, IL, interluekin, IL17A/F, IL17 A/F, IL-17A/F Interleukin-17 A/F, Interleukin-17 AF
Molecular Weight 31.0 kDa
Gene ID 3605
UniProt Q16552
Pathways TCR Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Comment

physical form description: Sterile filtered and lyophilized with no additives

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
Buffer Lyophilized with no additives
Preservative Without preservative
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Trinité, Ohlson, Voznesensky et al.: "An HIV-1 replication pathway utilizing reverse transcription products that fail to integrate." in: Journal of virology, Vol. 87, Issue 23, pp. 12701-20, 2013 (PubMed).

Bérubé, Roussel, Nattagh et al.: "Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ..." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22299-307, 2010 (PubMed).

Roussel, Houle, Chan et al.: "IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 8, pp. 4531-7, 2010 (PubMed).