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Details for Product No. ABIN413466

Interleukin 18 (IL18) (Active) Protein

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Protein Name
Synonyms IGIF, IL-18, IL-1g, IL1F4, Igif, Il-18, ChIL-18, IL18
Origin
»Alternatives Human
Source
»Alternatives Escherichia coli (E. coli)
Protein Type Recombinant
Biological Activity Active
Application
Western Blotting (WB), ELISA, Functional Studies (Func)
Pubmed 1 reference available
Catalog no. ABIN413466
Quantity 25 µg
Price
214.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Characteristics Biological activity: 5 ng/mL The ED50 as determined by dose-dependent stimulation of the IFNg by human PBMC co-stimulated with rh-IL-12 was found to be 5 ng/mL.
Purity > 98 % by SDS-PAGE and HPLC analysis
Sterility Sterile filtered
Endotoxin Level < 0.1 ng/μg
Alternative Name IL-18
Background Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important role in cell-mediated immune responses.
Synonyms: Human IL-18, IL-18, IL18, IL 18, h-IL-18, rh-IL-18, recombinant human IL-18, recombinant IL-18, IL, interluekin, Interferon-gamma-inducing factor, IGIF, IL-1g, IL-18, IL1F4, MGC12320, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Iboctadekin.
Molecular Weight 18.3 kDa
Gene ID 3606
UniProt Q14116
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in ice-cold H2O to a concentration of 0.5-1 µg/µL. The solution can be stored at 4 °C for 1 week. For storage, prepare appropriate aliquots and freeze them at -80 °C for future use.
Buffer PBS
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Kahlenberg, Thacker, Berthier et al.: "Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 6143-56, 2011 (PubMed).

Alternatives for antigen "Interleukin 18 (IL18)", type "Proteins"
Hosts (37), (10), (4)
Reactivities (38), (14), (13), (1), (1), (1), (1), (1), (1), (1), (1)
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