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Interleukin 18 (IL18) (Active) Protein
|Synonyms||IGIF, IL-18, IL-1g, IL1F4, MGC12320, Igif, Il-18, IL18|
Escherichia Coli (E. coli)
Western Blotting (WB), ELISA, Functional Studies (Func)
|1 reference available|
|Quantity||25 µg (Variants)|
|Price||214.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Endotoxin Level||<0.1 ng/µg|
Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important role in cell-mediated immune responses.
Synonyms: Human IL-18, IL-18, IL18, IL 18, h-IL-18, rh-IL-18, recombinant human IL-18, recombinant IL-18, IL, interluekin, Interferon-gamma-inducing factor, IGIF, IL-1g, IL-18, IL1F4, MGC12320, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Iboctadekin.
|Characteristics||The ED₅₀ as determined by dose-dependent stimulation of the IFNg by human PBMC co-stimulated with rh-IL-12 was found to be 5 ng/ml.|
|Molecular Weight||18.3 kDa|
|Handling Advice||Centrifuge the vial prior to opening.|
|Purity||>98% by SDS-PAGE and HPLC Endotoxin level is <0.1 ng per μg of IL-18.|
|Buffer||Sterile filtered and lyophilized from PBS|
Stability: 12 months
|Restrictions||For Research Use only|
Kahlenberg, Thacker, Berthier et al.: "Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 6143-56, 2011 (PubMed).
|Hosts||Escherichia Coli (E. coli) (36)|
|Reactivities||Human (39), Mouse (Murine) (9), Rat (Rattus) (8)|