Interleukin 18 (IL18) (Active) Protein

Details for Product No. ABIN413466
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Protein Name
Synonyms Igif, Il-18, IL-18, IGIF, ChIL-18, IL-1g, IL1F4, IL18
Origin
Human
(49), (16), (11), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Source
Escherichia coli (E. coli)
(58), (11), (5), (2)
Protein Type Recombinant
Biological Activity Active
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
Pubmed 4 references available
Quantity 25 μg
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Characteristics 18.3 kDa
Biological Activity: The ED₅₀ as determined by dose-dependent stimulation of the IFNg by human PBMC co-stimulated with rh-IL-12 was found to be 5 ng/mL.
Purity ≥98 %
Sterility Sterile filtered
Endotoxin Level <0.1 ng/μg
Alternative Name IL-18
Background Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important role in cell-mediated immune responses.
Synonyms: Human IL-18, IL-18, IL18, IL 18, h-IL-18, rh-IL-18, recombinant human IL-18, recombinant IL-18, IL, interluekin, Interferon-gamma-inducing factor, IGIF, IL-1g, IL-18, IL1F4, MGC12320, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Iboctadekin.
Molecular Weight 18.3 kDa
Gene ID 3606
UniProt Q14116
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in ice-cold H₂O to a concentration of 0.5-1 μg/μl.
Buffer Sterile filtered and lyophilized from PBS
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Moriwaki, Bertin, Gough et al.: "A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 4, pp. 1938-44, 2015 (PubMed).

Uzan, Poglio, Gerby et al.: "Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression." in: EMBO molecular medicine, Vol. 6, Issue 6, pp. 821-34, 2014 (PubMed).

Kahlenberg, Carmona-Rivera, Smith et al.: "Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 3, pp. 1217-26, 2013 (PubMed).

Kahlenberg, Thacker, Berthier et al.: "Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 6143-56, 2011 (PubMed).

Validation Images
Catalog No. ABIN413466
242.00 $
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Quantity
Price
25 μg
242.00 $

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