Interleukin 18 (IL18) (Active) Protein

Details for Product No. ABIN413466
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Protein Name
Synonyms Igif, Il-18, IL-18, IGIF, ChIL-18, IL-1g, IL1F4, IL18
Origin
Human
(46), (12), (10), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Source
Escherichia coli (E. coli)
(46), (10), (4), (2)
Protein Type Recombinant
Biological Activity Active
Application
Western Blotting (WB), ELISA, Functional Studies (Func)
Pubmed 1 reference available
Quantity 25 µg
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Catalog No. ABIN413466
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Characteristics Biological activity: 5 ng/mL The ED50 as determined by dose-dependent stimulation of the IFNg by human PBMC co-stimulated with rh-IL-12 was found to be 5 ng/mL.
Purity > 98 % by SDS-PAGE and HPLC analysis
Sterility Sterile filtered
Endotoxin Level < 0.1 ng/μg
Alternative Name IL-18
Background Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important role in cell-mediated immune responses.
Synonyms: Human IL-18, IL-18, IL18, IL 18, h-IL-18, rh-IL-18, recombinant human IL-18, recombinant IL-18, IL, interluekin, Interferon-gamma-inducing factor, IGIF, IL-1g, IL-18, IL1F4, MGC12320, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Iboctadekin.
Molecular Weight 18.3 kDa
Gene ID 3606
UniProt Q14116
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in ice-cold H2O to a concentration of 0.5-1 µg/µL. The solution can be stored at 4 °C for 1 week. For storage, prepare appropriate aliquots and freeze them at -80 °C for future use.
Buffer PBS
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Kahlenberg, Thacker, Berthier et al.: "Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 6143-56, 2011 (PubMed).

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