Interleukin 18 (IL18) (Active) Protein

Name: Interleukin 18 (IL18)

Synonyms: IGIF, IL-18, IL-1g, IL1F4, MGC12320, Igif, Il-18, IL18

Protein Type: Recombinant

Biological Activity: Active

Source: Escherichia Coli (E. coli)

Origin (Gene): Human

Application: Western Blotting (WB), ELISA, Functional Studies (Func)

Catalog no.: ABIN413466

Additional Information

Gene ID: 3606

UniProt: Q14116

Endotoxin Level: <0.1 ng/µg

Description: Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important role in cell-mediated immune responses.
Synonyms: Human IL-18, IL-18, IL18, IL 18, h-IL-18, rh-IL-18, recombinant human IL-18, recombinant IL-18, IL, interluekin, Interferon-gamma-inducing factor, IGIF, IL-1g, IL-18, IL1F4, MGC12320, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Iboctadekin.

Characteristics: The ED₅₀ as determined by dose-dependent stimulation of the IFNg by human PBMC co-stimulated with rh-IL-12 was found to be 5 ng/ml.

Molecular Weight: 18.3 kDa

Application Details

Handling Advice: Centrifuge the vial prior to opening.

Purity: >98% by SDS-PAGE and HPLC Endotoxin level is <0.1 ng per μg of IL-18.

Buffer: Sterile filtered and lyophilized from PBS

Storage: -20°C.
Stability: 12 months

Restrictions: For Research Use only

Publications

Product: Kahlenberg, Thacker, Berthier et al.: "Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 6143-56, 2011 (PubMed).