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Interleukin 1, beta (IL1B) (Active) Protein

Details for Product No. ABIN413478, Supplier: Login to see New
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Protein Name
(77), (58), (23), (9), (6), (6), (6), (6), (5), (5), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Escherichia coli (E. coli)
(163), (18), (3), (2), (2), (2), (2), (1), (1), (1)
Protein Type Recombinant
Biological Activity Active
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
Pubmed 2 references available
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Quantity 10 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Characteristics 17.0 kDa
Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by murine C3H/HeJ thymocytes is <0.1 ng/mL, corresponding to a specific activity of >1 x 10⁷ units/mg.
Purity ≥98 %
Endotoxin Level <0.1 ng/μg
Background IL-1beta is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses including the activation of B and T cells. Recombinant human IL-1beta is a 17.0 kDa protein containing 153 amino acid residues.
Synonyms: Human IL-1beta, IL-1beta, IL1beta, IL 1beta, h- IL-1beta, rh-IL-1beta, recombinant human IL-1beta, recombinant IL-1beta, IL, interluekin, Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Molecular Weight 17.0 kDa
Gene ID 3553
UniProt P01584
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Pathways NF-kappaB Signaling, TCR Signaling, Interferon-gamma Pathway
Application Notes Optimal working dilution should be determined by the investigator.

physical form description: Lyophilized with no additives.

Restrictions For Research Use only
Format Lyophilized
Reconstitution We recommend a quick spin followed by reconstitution in H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or stored at -20 °C for future use.
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: von Burg, Chappaz, Baerenwaldt et al.: "Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 35, pp. 12835-40, 2014 (PubMed).

Kahlenberg, Thacker, Berthier et al.: "Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 6143-56, 2011 (PubMed).

Catalog No. ABIN413478
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