Interleukin 1, beta (IL1B) (Active) Protein

Details for Product No. ABIN413478
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Protein Name
Synonyms il1-b, zgc:111873, IL-1beta, Il-1b, IL1B, IL-1, IL1-BETA, IL1F2, IL-1BETA, IL1beta, IL-1B
Origin
Human
(89), (67), (30), (12), (10), (6), (4), (4), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Source
Escherichia coli (E. coli)
(174), (16), (6), (6), (2), (2), (2), (1)
Protein Type Recombinant
Biological Activity Active
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
Pubmed 1 reference available
Quantity 10 μg
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Characteristics 17.0 kDa
Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by murine C3H/HeJ thymocytes is <0.1 ng/mL, corresponding to a specific activity of >1 x 10⁷ units/mg.
Purity ≥98 %
Endotoxin Level <0.1 ng/μg
Alternative Name IL-1 beta
Background IL-1beta is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses including the activation of B and T cells. Recombinant human IL-1beta is a 17.0 kDa protein containing 153 amino acid residues.
Synonyms: Human IL-1beta, IL-1beta, IL1beta, IL 1beta, h- IL-1beta, rh-IL-1beta, recombinant human IL-1beta, recombinant IL-1beta, IL, interluekin, Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Molecular Weight 17.0 kDa
Gene ID 3553
UniProt P01584
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Application Notes Optimal working dilution should be determined by the investigator.
Comment

physical form description: Lyophilized with no additives.

Restrictions For Research Use only
Format Lyophilized
Reconstitution We recommend a quick spin followed by reconstitution in H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or stored at -20 °C for future use.
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Kahlenberg, Thacker, Berthier et al.: "Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 6143-56, 2011 (PubMed).

Validation Images
Catalog No. ABIN413478
225.50 $
Plus shipping costs $45.00
Quantity
Price
10 μg
225.50 $

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