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Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (Active) Protein

Details for Product No. ABIN413778, Supplier: Log in to see
Protein Name
  • a-sdf1a
  • IRH
  • PBSF
  • Pbsf
  • Scyb12
  • SCYB12
  • sdf-1
  • SDF-1
  • sdf1
  • Sdf1
  • SDF1
  • sdf1a
  • Tlsf
  • TLSF
  • TPAR1
  • Tpar1
  • xSDF-1
Origin
Human
71
41
19
7
2
1
1
1
1
1
Source
Escherichia coli (E. coli)
105
3
2
1
1
Protein Type
Recombinant
Biological Activity
Active
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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Characteristics Biological Activity: Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentration range of 20-80 ng/mL.
Purity ≥98 %
Sterility Sterile filtered
Endotoxin Level <0.1 ng/μg
Background Human Stromal Cell-Derived Factor-1alpha (SDF-1alpha) is a recently discovered protein belonging to the alpha-chemokine (C-X-C) family of cytokines. Human SDF-1alpha is an 8.0 kDa protein containing 68 AA residues with N-terminus His-tag
Synonyms: Human SDF-1alpha, h-SDF-1alpha,SDF-1alpha, SDF1alpha,SDF 1alpha, rh-SDF-1alpha, recombinant human SDF-1alpha, recombinant SDF-1alpha, SDF, SDF-1, CXCL12, Pre-B cell growth-stimulating factor, PBSF, hIRH, chemokine (C-X-C motif) ligand 12, SDF1, SDF1A, TPAR1, SCYB12, SDF-1a, TLSF-a.
Molecular Weight 8.0 kDa
Gene ID 6387
UniProt P48061
Research Area Growth Factors
Application Notes Optimal working dilution should be determined by the investigator.
Comment

physical form description: Sterile filtered and lyophilized with no additives

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitution in H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers or stored at 4 °C for 1 week or -20 °C for future use.
Buffer Lyophilized with no additives
Preservative Without preservative
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: di Tomaso, Snuderl, Kamoun, Duda, Auluck, Fazlollahi, Andronesi, Frosch, Wen, Plotkin, Hedley-Whyte, Sorensen, Batchelor, Jain: "Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape." in: Cancer research, Vol. 71, Issue 1, pp. 19-28, 2011 (PubMed).

Basu, Ray, Atkinson, Broxmeyer: "Protein phosphatase 2A plays an important role in stromal cell-derived factor-1/CXC chemokine ligand 12-mediated migration and adhesion of CD34+ cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 5, pp. 3075-85, 2007 (PubMed).

Basu, Broxmeyer: "Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12." in: Blood, Vol. 106, Issue 2, pp. 485-93, 2005 (PubMed).

Miwa, Mizokami, Keller, Taichman, Zhang, Namiki: "The bisphosphonate YM529 inhibits osteolytic and osteoblastic changes and CXCR-4-induced invasion in prostate cancer." in: Cancer research, Vol. 65, Issue 19, pp. 8818-25, 2005 (PubMed).