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Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (Active) Protein

Details for Product No. ABIN413778, Supplier: Log in to see
Protein Name
  • sdf1a
  • a-sdf1a
  • IRH
  • PBSF
  • SCYB12
  • SDF1
  • TLSF
  • TPAR1
  • Pbsf
  • Scyb12
  • Sdf1
  • Tlsf
  • Tpar1
  • sdf-1
  • sdf1
  • xSDF-1
  • SDF-1
  • chemokine (C-X-C motif) ligand 12
  • CXCL12
  • stromal cell-derived factor 1a
  • CXCL12
  • LOC100304642
  • sdf1a
  • a-sdf1a
  • Cxcl12
  • cxcl12
Origin
Human
70
42
16
7
1
1
1
1
Source
Escherichia coli (E. coli)
99
3
2
1
1
Protein Type
Recombinant
Biological Activity
Active
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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Purity ≥98 %
Sterility Sterile filtered
Endotoxin Level <0.1 ng/μg
ProductDetails: Biological Activity Comment Biological Activity: Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentration range of 20-80 ng/ml.
Background Human Stromal Cell-Derived Factor-1alpha (SDF-1alpha) is a recently discovered protein belonging to the alpha-chemokine (C-X-C) family of cytokines. Human SDF-1alpha is an 8.0 kDa protein containing 68 AA residues with N-terminus His-tag
Synonyms: Human SDF-1alpha, h-SDF-1alpha,SDF-1alpha, SDF1alpha,SDF 1alpha, rh-SDF-1alpha, recombinant human SDF-1alpha, recombinant SDF-1alpha, SDF, SDF-1, CXCL12, Pre-B cell growth-stimulating factor, PBSF, hIRH, chemokine (C-X-C motif) ligand 12, SDF1, SDF1A, TPAR1, SCYB12, SDF-1a, TLSF-a.
Molecular Weight 8.0 kDa
Gene ID 6387
UniProt P48061
Research Area Growth Factors
Pathways Regulation of Cell Size
Application Notes Optimal working dilution should be determined by the investigator.
Comment

physical form description: Sterile filtered and lyophilized with no additives

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitution in H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers or stored at 4 °C for 1 week or -20 °C for future use.
Preservative Without preservative
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: di Tomaso, Snuderl, Kamoun, Duda, Auluck, Fazlollahi, Andronesi, Frosch, Wen, Plotkin, Hedley-Whyte, Sorensen, Batchelor, Jain: "Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape." in: Cancer research, Vol. 71, Issue 1, pp. 19-28, 2011 (PubMed).

Basu, Ray, Atkinson, Broxmeyer: "Protein phosphatase 2A plays an important role in stromal cell-derived factor-1/CXC chemokine ligand 12-mediated migration and adhesion of CD34+ cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 5, pp. 3075-85, 2007 (PubMed).

Basu, Broxmeyer: "Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12." in: Blood, Vol. 106, Issue 2, pp. 485-93, 2005 (PubMed).

Miwa, Mizokami, Keller, Taichman, Zhang, Namiki: "The bisphosphonate YM529 inhibits osteolytic and osteoblastic changes and CXCR-4-induced invasion in prostate cancer." in: Cancer research, Vol. 65, Issue 19, pp. 8818-25, 2005 (PubMed).