Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (Active) Protein

Name: Chemokine (C-X-C Motif) Ligand 12 (CXCL12)

Synonyms: CXCL12, DKFZp469G1525, PBSF, SDF1, SDF1A, SDF1B, TPAR1, SCYB12, SDF-1a, SDF-1b, TLSF-a, TLSF-b, Pbsf, Sdf1, Tlsf, Sdf1a, Sdf1b, Tlsfa, Tlsfb, Tpar1, Scyb12, AI174028, sdf1a, a-sdf1a

Protein Type: Recombinant

Biological Activity: Active

Source: Escherichia Coli (E. coli)

Origin (Gene): Human

Application: Western Blotting (WB), ELISA, Functional Studies (Func)

Catalog no.: ABIN413780

Additional Information

Gene ID: 6387

UniProt: P48061

Endotoxin Level: <0.1 ng/µg

Description: Human Stromal Cell-Derived Factor-1alpha (SDF-1alpha) is a recently discovered protein belonging to the alpha-chemokine (C-X-C) family of cytokines. Human SDF-1alpha is an 8.0 kDa protein containing 68 amino acids residues with N-terminus His-tag
Synonyms: Human SDF-1alpha, h-SDF-1alpha,SDF-1alpha, SDF1alpha,SDF 1alpha, rh-SDF-1alpha, recombinant human SDF-1alpha, recombinant SDF-1alpha, SDF, SDF-1, CXCL12, Pre-B cell growth-stimulating factor, PBSF, hIRH, chemokine (C-X-C motif) ligand 12, SDF1, SDF1A, TPAR1, SCYB12, SDF-1a, TLSF-a.

Characteristics: Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentration range of 20-80 ng/ml.

Molecular Weight: 8.0 kDa

Application Details

Handling Advice: Centrifuge the vial prior to opening.

Purity: >98% by SDS-PAGE and HPLC analyses Endotoxin level is <0.1 ng per μ g (1EU/ μ g).

Buffer: Sterile filtered and lyophilized with no additives

Storage: -20°C.
Stability: 12 months

Restrictions: For Research Use only

Publications

Product: Basu, Broxmeyer: "Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12." in: Blood, Vol. 106, Issue 2, pp. 485-93, 2005 (PubMed).

Miwa, Mizokami, Keller et al.: "The bisphosphonate YM529 inhibits osteolytic and osteoblastic changes and CXCR-4-induced invasion in prostate cancer." in: Cancer research, Vol. 65, Issue 19, pp. 8818-25, 2005 (PubMed).

Basu, Ray, Atkinson et al.: "Protein phosphatase 2A plays an important role in stromal cell-derived factor-1/CXC chemokine ligand 12-mediated migration and adhesion of CD34+ cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 5, pp. 3075-85, 2007 (PubMed).

di Tomaso, Snuderl, Kamoun et al.: "Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape." in: Cancer research, Vol. 71, Issue 1, pp. 19-28, 2011 (PubMed).